Alkyl indane aldehyde compounds

ABSTRACT

The present invention relates, inter alia, to novel alkyl indane aldehyde compounds having fragrant musk-like aroma.

RELATED APPLICATION

This application is a continuation-in-part of patent application U.S. Ser. No. 079,008, filed Jun. 18, 1993, now U.S. Pat. No. 5,292,720, the disclosures of which are hereby incorporated herein by reference in their entirety.

BACKGROUND OF THE INVENTION

The present invention relates, inter alia, to novel alkyl indane aldehyde compounds having fragrant musk-like aroma.

Musk has been a highly valued fragrance for decades, finding use in numerous products such as in perfumes, colognes, soaps, cosmetics, as well as others. Natural musk is obtained from the glands of the endangered tiny musk deer of Central Asia, Moschus moschiferous, commonly referred to as the Asian musk deer. Such natural musk, however, is extremely scarce and expensive. Accordingly, fragrance chemists around the world have spent considerable time and effort searching for synthetic products which duplicate or closely simulate the natural musk scent.

As a result of such research efforts, a number of different synthetic musks have been discovered. Among such synthetic compounds are the acetyl indanes described by Sprecker et al., U.S. Pat. No. 4,466,908, compounds of the formulas ##STR1## Similarly, Fehr et al., Helvetica Chimica Acta, Vol. 72, pp. 1537-1553 (1989) discusses such synthetic musks as those of the formula ##STR2## wherein R is either H or CH₃.

Traas et al., U.S. Pat. No. 4,352,748 discloses formylated and acetylated indane musks, including those of the formulas ##STR3##

Other acetyl indanes, such as 6-acetyl-1,1,3,3,5-pentamethylindane, 5-acetyl-1,1,2,3,3-pentamethylindane and 6-acetyl-5-ethyl-1,1,2,3,3-pentamethylindane, are disclosed in French Patent No. 1,392,804 (as reported in Chemical Abstracts, Vol. 63, p. 1681d (1965)).

Cobb et al., U.S. Pat. No. 4,551,573, also discusses various indane compounds.

New and or better musk aroma compounds are needed to meet the demands of the fragrance industries. The present invention is directed to these, as well as other, important ends.

SUMMARY OF THE INVENTION

The present invention provides novel compounds of the formula [I]: ##STR4## wherein R¹ is H, CH₃, CH₂ CH₃, OCH₃ or OH,

R² and R³ are, independently, H, CH₃, CH₂ CH₃, OCH₃, OH or C(O)H,

R⁴ and R⁷ are, independently, H, CH₃, CH₂ CH₃ or CH(CH₃)₂,

R⁵ and R⁸ are, independently H or CH₃, and

R⁶ is H, CH₃ or CH₂ CH₃, provided that

(i) one of R² and R³ is C(O)H, and one of R² and R³ is other than C(O)H,

(ii) when R¹ is H, then R² and R³ are other than OCH₃ or OH,

(iii) when R¹ is other than H, then R⁷ is CH₃ or CH₂ CH₃,

(iv) no more than one of R⁴, R⁶ and R⁷ is CH₂ CH₃ or CH(CH₃)₂,

(v) no more than one of R⁴, R⁵, R⁶, R⁷ and R⁸ is H,

(vi) when each of R¹, R³, R⁴ and R⁵ are CH₃, then R⁸ is H,

(vii) when R⁴ is CH(CH₃)₂, then at least one of R⁵ or R⁶ is H,

(viii) when R⁷ is CH(CH₃)₂, then at least one of R⁶ or R⁸ is H,

(ix) when R¹ is OCH₃, then R² and R³ are other than OH,

(x) when R¹ is OH, then R² and R³ are other than OH or OCH₃,

(xi) when R¹ is H, R⁴ is CH(CH₃)₂ and R⁵ is CH₃, then one of R² and R³ is CH₂ CH₃,

(xii) when R¹ is H, R⁷ is CH(CH₃)₂ and R⁸ is CH₃, then one of R² and R³ is CH₂ CH₃,

(xiii) when R¹ is H, R⁷ is CH(CH₃)₂ and R⁸ is H, then R³ is C(O)H,

(xiv) when R¹ is H, R⁴ is CH(CH₃)₂ and R⁵ is H, then R² is C(O)H,

(xv) when R¹ is H, R⁷ is CH₂ CH₃ and R⁴, R⁵ and R⁸ are CH₃, then both of R² and R³ are other than CH₃,

when R¹ is H, R⁴ is CH₂ CH₃ and R⁵, R⁷ and R⁸ are CH₃, then both of R² and R³ are other than CH₃, and

(xvii) when one of R² and R³ is CH₃, and each of R⁴, R⁵, R⁶, R⁷ and R⁸ are CH₃, then R¹ is other than H.

The foregoing compounds possess an active musk aroma having utility in the fragrance industry. The compounds of the invention may be used alone, or in combination with carriers, additional perfumery materials, and/or other ingredients, to provide various products, such as perfumes, colognes, soaps, and cosmetics.

DETAILED DESCRIPTION OF THE INVENTION

As noted above, the present invention is directed to novel musk compounds of the formula [I]: ##STR5##

In the above formula [I], the R substituents may be selected as follows: R¹ may be selected from the group consisting of H, CH₃, CH₂ CH₃, OCH₃ and OH; R² may be selected from the group consisting of H, CH₃, CH₂ CH₃, OCH₃, OH and C(O)H; R³ may be selected from the group consisting of H, CH₃, CH₂ CH₃, OCH₃, OH and C(O)H; R⁴ may be selected from the group consisting of H, CH₃, CH₂ CH₃ and CH(CH₃)₂ ; R⁵ may be selected from the group consisting of H and CH₃ ; R⁶ may be selected from the group consisting of H, CH₃ and CH₂ CH₃ ; R⁷ may be selected from the group consisting of H, CH₃, CH₂ CH₃ and CH(CH₃)₂ ; and R⁸ may be selected from the group consisting of H and CH₃.

The foregoing selection of R substituents should, however, be made with the following qualifications in mind: that one of R² and R³ is C(O)H, and the other of R² and R³ is other than C(O)H; that when R¹ is H, then R² and R³ are both other than OCH₃ or OH; that when R¹ is other than H, then R⁷ is either CH₃ or CH₂ CH₃ ; that no more than one of R⁴, R⁶ and R⁷ is either CH₂ CH₃ or CH(CH₃)₂ ; that no more than one of R⁴, R⁵, R⁶, R⁷ and R⁸ is H; that when all of R¹, R³, R⁴ and R⁵ are CH₃, then R⁸ is H; that when R⁴ is CH(CH₃)₂, then one or both of R⁵ or R⁶ is H; that when R.sup. 7 is CH(CH₃)₂, then one or both of R⁶ or R⁸ is H; that when R¹ is OCH₃, then R² and R³ are both other than OH; that when R¹ is OH, then R² and R³ are both other than either OH or OCH₃ ; that when all of the following is true--R¹ is H, R⁴ is CH(CH₃)₂ and R⁵ is CH₃ --then one of R² and R³ is CH₂ CH₃ ; that when all of the following is true--R¹ is H, R⁷ is CH(CH₃)₂ and R⁸ is CH₃ --then one of R² and R³ is CH₂ CH₃ ; that when all of the following is true--R¹ is H, R⁷ is CH(CH₃)₂ and R⁸ is H--then R³ is C(O)H; that when all of the following is true--R¹ is H, R⁴ is CH(CH₃)₂ and R⁵ is H--then R² is C(O)H; that when all of the following is true--R¹ is H, R⁷ is CH₂ CH₃ and R⁴, R⁵ and R⁸ are CH₃ --then both of R² and R³ are other than CH₃ ; that when all of the following is true--when R¹ is H, R⁴ is CH₂ CH₃ and R⁵, R⁷ and R⁸ are CH₃ --then both of R² and R³ are other than CH₃ ; and that when all of the following is true--one of R² and R³ is CH₃, and each of R⁴, R⁵, R⁶, R⁷ and R⁸ are CH₃ --then R¹ is other than H.

For reasons of their fragrance characteristics, synthesis advantages, formulation benefits, and/or other values, the following are preferable classes of compounds within the scope of Formula [I]:

Compounds of Formula [I] wherein R² is C(O)H.

Compounds of Formula [I] wherein at least one (that is, one or more) of R¹, R² and R³ are, independently OCH₃ or OH.

Compounds of Formula [I] wherein at least one (that is, one or more) of R¹, R² and R³ are OCH₃.

Compounds of Formula [I] wherein R¹ is H, CH₃, CH₂ CH₃ or OCH₃, and R² and R³ are, independently, H, CH₃, CH₂ CH₃, OCH₃ or C(O)H.

Compounds of Formula [I] wherein R¹ is H, CH₃ or OCH₃, and R² and R³, independently, are H, CH₃, OCH₃ or C(O)H.

Compounds of Formula [I] wherein at least one (that is, one or more) of R⁴ or R⁷ are H, CH₃ or CH₂ CH₃.

Compounds of Formula [I] wherein R⁴ and R⁷ are, independently, CH₃, CH₂ CH₃ or CH(CH₃)₂, and R⁵ and R⁸ are CH₃.

Compounds of Formula [I] wherein R⁴ and R⁷ are, independently, CH₃, CH₂ CH₃ or CH(CH₃)₂, R⁵ and R⁸ are CH₃ and R⁶ is CH₃ or CH₂ CH₃.

Compounds of Formula [I] wherein R⁴ is CH(CH₃)₂.

Specific compounds of Formula [I] which are most preferred, for reasons of fragrance characteristics, synthesis advantages, formulation benefits, and/or other values are as follows:

The compound of Formula [I] wherein compound of Claim 1 wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is CH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₂ CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH₂ CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₂ CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₂ CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₂ CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is CH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is OCH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.

The compound of Formula [I] wherein R¹ is H, R² is C(O)H, R³ is CH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.

The novel alkyl indane aldehyde compounds of the present invention may be prepared in various fashions. In the preferable protocol, alkyl indanes are first prepared. Then the alkyl indanes are formylated (that is, the radical --C(O)H is added to the benzene ring of the indane structure, to form an alkylated indane aldehyde), or oxidized (that is, a --CH₃ substituent on the benzene ring of the indane structure is oxidized to --C(O)H, to form an alkyl indane aldehyde), yielding the alkyl indane aldehyde compounds of Formula [I]. Examples 1-6 illustrate specific methodology which may be utilized for the preparation of compounds of the present invention.

In general, alkyl indane compounds or alkyl indane aldehyde compounds may be prepared by numerous synthetic routes which will be readily apparent to those skilled in the art, once armed with the present disclosure. Examples of suitable methodology which may be employed or modified in accordance with the present invention to prepare such compounds include Fehr et al., U.S. Pat. Nos. 5,162,588, Cobb et al., 4,551,573, Gozenbach et al., 4,406,828, Traas et al., 4,352,748, Sprecker et al, 4,162,256, 4,466,908 and 4,652,400, Wood et al., 3,509,215, Stofberg et al., 3,278,622, Frank, 5,095,152, 5,087,770, 5,087,785, and 5,206,217, DeSimone, 4,018,719, Fehr et al., Helvetica Chimica Acta, Vol. 72, pp. 1537-1553 (1989), European Patent Application Publication No. 0,393,742, Great Britain Patent No. 1,459,036, Japanese Patent No. SHO 50-40761, and French Patent No. 1,392,804 (also reported in Chemical Abstracts, Vol. 63, p. 1681d (1965), the disclosures of each of which are hereby incorporated herein by reference, in their entirety. Modifications of such methodology sufficient to enable preparation of the specific novel compounds of the present invention will be readily apparent to those skilled in the art once placed in possession of the present invention.

In accordance with Frank, U.S. Pat. Nos. 5,087,785 and 5,087,770, for example, alkyl indanes may be prepared by isomerizing an alkylated tetrahydronaphthalene in the presence of (i) a Lewis acid (the Lewis acid being present in an amount of less than about 50 mole percent based on the amount of the alkylated tetrahydronaphthalene), and (ii) a solvent which can be a halogenated or unhalogenated solvent and, optionally, (iii) a phase transfer agent. Exemplary Lewis acids include titanium chloride, aluminum chloride and aluminum bromide. Exemplary halogenated solvents include dichloromethane, trichloromethane and 1,2-dichloroethane, and exemplary unhalogenated solvents include cyclohexane. Exemplary phase transfer agents include methyltrioctylammonium chloride and a mixture of methyltrioctylammonium chloride and methyltridecylammonium chloride (marketed under the trademark ADOGEN-464™, by Sherex Co., Dublin, Ohio).

In the foregoing process, the molar proportions of the reagents can be varied over a relatively wide range, provided that the Lewis acid is present in an amount of less than about 50 mole percent based on the amount of the alkylated tetrahydronaphthalene starting material, the precise amounts of the reagents being dependent upon such factors as the particular solvent employed, the presence or absence of a phase transfer agent, and the specific tetrahydronaphthalene starting material and other reaction conditions such as time, temperature, pressure, etc. Suitable reagent amounts will be well within the ambit of those skilled in the art, once armed with the present disclosures.

Although, in general, the molar proportions of the reagents employed in the process may be relatively widely varied, for best results, however, it is important to maintain a ratio of less than one mole of phase transfer agent per mole of Lewis acid. Preferably, the molar ratio is about 0.8 to 1.0, more preferably about 0.5 to 1.0, phase transfer agent to Lewis acid.

The subject isomerization reaction may be carried out in any suitable vessel which provides sufficient contacting between the Lewis acid, the phase transfer agent and the other reactants. For simplicity, a stirred batch reactor can be employed. The reaction vessel used should be resistant to the possible corrosive nature of the Lewis acid, such as a glass-lined vessel. The reagents of the present process may be added to the vessel in any order, although generally the solvent, the alkylated tetrahydronaphthalene, and any phase transfer agent are added first, followed by Lewis acid addition. The reaction may be carried out over a wide temperature range, but is preferably carried out at temperatures from about 0° C. to about 20° C. The pressure at which the reaction is carried out and the type of atmosphere are not critical. Generally, the isomerization reaction proceeds to equilibrium in about 1 to about 8 hours.

Product can be recovered from the reaction mixture by first quenching the reaction mixture in cold water or on crushed ice, preferably on ice, and then processing the mixture in the usual manner for Friedel-Crafts reactions to extract the indane compounds. Suitable extraction protocol is described, for example, in George A. Olah, Friedel-Crafts And Related Reactions, Vols. 1 and 2 (Interscience Publishers, John Wiley and Sons, New York, N.Y. 1964), the disclosures of which are hereby incorporated by reference in their entirety. Typically, following quenching and the resultant phase separation, the organic layer is washed an additional time with water to aid in removal of the Lewis acid. One or more additional washings can be carried out with dilute alkali solution to further aid Lewis acid removal. The resultant product is generally a mixture of the alkylated tetrahydronaphthalene starting material and the desired secondary alkyl indane isomerates. A more purified product may be obtained by subjecting the washed reaction mixture to reduced pressure fractional distillation, commercial chromatographic separation or other separation means known to those skilled in the art.

Alkylated tetrahydronaphthalene starting materials may be obtained commercially, or prepared using numerous well known procedures including those disclosed in Frank, U.S. Pat. Nos. 4,877,911, 4,877,914, 4,877,910, 4,877,916, 4,877,915, 4,877,913 and 4,877,912, Cobb et al., 4,551,573, Japanese Patent No. SHO 57-40420, Wood, U.S. Pat. Nos. 3,246,044, Wood et al., 3,856,875, Sato et al., 4,284,818, Kahn, 3,379,785, Suzukamo et al., 4,767,882, the disclosures of each of which are hereby incorporated herein by reference, in their entirety.

Alkyl indane compounds may then be formylated or oxidized to form alkyl indane aldehydes using conventional formylation or oxidation technology, as will be readily apparent to those skilled in the art, once armed with the present disclosure.

For example, alkyl indane compounds may be formylated using the following formylation process. Specifically, to prepare alkyl indane aldehyde compounds of the present invention, the alkyl indanes may be preferably reacted with α,α-dichloromethyl methyl ether, in a solvent such as an organic solvent (preferably a halogenated organic solvent such as, for example, anhydrous dichloromethane), in the presence of a Lewis acid (preferably titanium chloride; TiCl₄). Other suitable halogenated solvents and Lewis acids are discussed above, and will be readily apparent to those skilled in the art, once armed with the present disclosures. In general, formylation methods are well known in the art and are described, for example, in Organic Syntheses, Collective Vol. 5, pp. 49-50, by A. Rieche, H. Gross, and E. Hoft, edited by H. E. Baumgarten, John Wiley and Sons (New York, N.Y. 1973), Rahm, Synthetic Communications, Vol. 12, No. 6, pp. 485-487 (1982), Effenberger, Angewandte Chemie International Edition (English), Vol. 19, No. 3, pp. 151-230 (1980), Olah et al., Chemical Reviews, Vol. 87, No. 4, pp. 671-686 (1987), and Hauser et al., Synthesis, pp. 723-724 (August 1987), the disclosures of each of which are hereby incorporated herein by reference, in their entirety.

Alternatively, to prepare alkyl indane aldehydes from alkyl indanes using oxidation techniques, the alkyl indanes are preferably reacted with ceric ammonium nitrate (Ce(NO₃)₄. NH₄ NO₃), a strong oxidant for organic compounds, in the presence of acetic acid. In general, these and other suitable oxidation methods are well known in the art, and are described, for example, in Syper, Tetrahedron Letters, No. 37, pp. 4493-4498 (1966), Laing et al., J. Chem. Soc. (C), pp. 2915-2918 (1968), Imamoto et al., Chemistry Letters, pp. 1445-1446 (1990), Kreh et al., Tetrahedron Letters, Vol. 28, No. 10, pp. 1067-1068 (1987), Hauser et al., Communications, pp. 72-73 (August 1987), and Syper, Tetrahedron Letters, No. 42, pp. 4193-4198 (1967).

Further purification of the alkyl indane aldehyde compounds of Formula [I] may be carried out, if desired, using, for example, standard fractional distillation techniques, as well as other conventional extraction, distillation, crystallization and chromatography techniques, and the like.

Exemplary alkyl indane aldehyde compounds are shown in Table I below.

                                      TABLE I                                      __________________________________________________________________________     Compound                                                                             R.sup.1                                                                             R.sup.2                                                                             R.sup.3                                                                             R.sup.4                                                                              R.sup.5                                                                           R.sup.6                                                                             R.sup.7                                                                              R.sup.8                               __________________________________________________________________________      1    H    H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                               2    H    H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                               3    H    H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                               4    H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                               5    H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                               6    H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            H     CH.sub.3                               7    H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                               8    H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                      9    H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   H                                     10    H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     11    H    H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              12    H    H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              13    H    H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            H     CH.sub.3                              14    H    H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              15    H    CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              16    H    CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              17    H    CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              18    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              19    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              20    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            H     CH.sub.3                              21    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                              22    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     23    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   H                                     24    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              25    H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            H     CH.sub.3                              26    H    CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              27    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              28    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              29    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              30    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              31    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              32    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH(CH.sub.3).sub.2                                                                   CH.sub.3                              33    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            H     CH.sub.3                              34    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                              35    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     36    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   H                                     37    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              38    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              39    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            H     CH.sub.3                              40    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              41    H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              42    CH.sub.3                                                                            H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              43    CH.sub.3                                                                            H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              44    CH.sub.3                                                                            H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              45    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              46    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              47    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     48    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub. 3                                                                         CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     49    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     50    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              51    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              52    CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     53    CH.sub.3                                                                            H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              54    CH.sub.3                                                                            H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              55    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              56    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              57    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              58    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              59    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              60    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     61    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     62    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     63    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              64    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              65    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     66    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              67    CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              68    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              69    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              70    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              71    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              72    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub. 3                                                                            CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              73    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     74    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     75    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     76    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              77    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              78    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     79    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              80    CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              81    CH.sub.3                                                                            C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              82    CH.sub.3                                                                            C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              83    CH.sub.3                                                                            C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              84    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              85    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              86    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     87    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     88    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     89    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              90    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              91    CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     92    CH.sub.3                                                                            C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              93    CH.sub.3                                                                            C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              94    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              95    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              96    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              97    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     98    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     99    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     100   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              101   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              102   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     103   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              104   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              105   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              106   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              107   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              108   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              109   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              110   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     111   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     112   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     113   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              114   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              115   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     116   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              117   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              118   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              119   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              120   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              121   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              122   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              123   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     124   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     125   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     126   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              127   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              128   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     129   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              130   CH.sub.2 CH.sub. 3                                                                  H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              131   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              132   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              133   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              134   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              135   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              136   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     137   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     138   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     139   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              140   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              141   CH.sub. 2 CH.sub.3                                                                  CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     142   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              143   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH3                                   144   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              145   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              146   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              147   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              148   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              149   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     150   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     151   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     152   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              153   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              154   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     155   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              156   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              157   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              158   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              159   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              160   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              161   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              162   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     163   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     164   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     165   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              166   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              167   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     168   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              169   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              170   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              171   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              172   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              173   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              174   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              175   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     176   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     177   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     178   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              179   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              180   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     181   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              182   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              183   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              184   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              185   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              186   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              187   CH.sub.2 CH.sub.3                                                                   OC(O)H                                                                              CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              188   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     189   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     190   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     191   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              192   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              193   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     194   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              195   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              196   OCH.sub.3                                                                           H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              197   OCH.sub.3                                                                           H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              198   OCH.sub.3                                                                           H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              199   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              200   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              201   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     202   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     203   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     204   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              205   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              206   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     207   OCH.sub.3                                                                           H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              208   OCH.sub.3                                                                           H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              209   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              210   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              211   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              212   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              213   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              214   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     215   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     216   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     217   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              218   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              219   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     220   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              221   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              222   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              223   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              224   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              225   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              226   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              227   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     228   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     229   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     230   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              231   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              232   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     233   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              234   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              235   OCH.sub.3                                                                           C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              236   OCH.sub.3                                                                           C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              237   OCH.sub.3                                                                           C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              238   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              239   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              240   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     241   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     242   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     243   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              244   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              245   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     246   OCH.sub.3                                                                           C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              247   OCH.sub.3                                                                           C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              248   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              249   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              250   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              251   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              252   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              253   OCH.sub. 3                                                                          C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     254   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     255   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     256   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              257   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              258   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     259   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              260   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              261   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              262   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              263   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              264   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              265   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              266   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     267   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     268   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     269   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              270   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              271   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     272   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              273   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              274   OH   H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              275   OH   H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub. 3                             276   OH   H    C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              277   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              278   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              279   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     280   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     281   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     282   OH   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              283   OH   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              284   OH   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     285   OH   H    C(O)H                                                                               CH(CH.sub.3)                                                                         H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              286   OH   H    C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              287   OH   CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              288   OH   CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              289   OH   CH.sub.3                                                                            C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              290   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              291   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              292   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     293   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     294   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     295   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              296   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              297   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     298   OH   CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              299   OH   CH.sub.3                                                                            C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              300   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              301   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              302   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              303   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              304   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              305   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     306   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     307   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     308   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              309   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              310   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     311   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              312   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              313   OH   C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub. 3                                                                            CH.sub.3                              314   OH   C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              315   OH   C(O)H                                                                               H    H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              316   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              317   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              318   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     319   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     320   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     321   OH   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              322   OH   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              323   OH   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     324   OH   C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              325   OH   C(O)H                                                                               H    CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              326   OH   C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              327   OH   C(O)H                                                                               CH.sub.3                                                                            H     CH.sub. 3                                                                         CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              328   OH   C(O)H                                                                               CH.sub.3                                                                            H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              329   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              330   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              331   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     332   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     333   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     334   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              335   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              336   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     337   OH   C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              338   OH   C(O)H                                                                               CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              339   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              340   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              341   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              342   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H  CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              343   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              344   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              345   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     346   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     347   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     348   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              349   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              350   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     351   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3 ).sub.2                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              352   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              353   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              354   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              355   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              356   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              357   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              358   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     359   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     360   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     361   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              362   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              363   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub. 3                                                                   CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     364   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              365   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              366   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              367   CH.sub.3                                                                            OH   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              368   CH.sub.3                                                                            OH   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              369   CH.sub.3                                                                            OH   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              370   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              371   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              372   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     373   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     374   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     375   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              376   CH.sub. 3                                                                           OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             H                                     377   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     378   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              379   CH.sub.3                                                                            OH   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              380   CH.sub.3                                                                            OH   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              381   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              382   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              383   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              384   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              385   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              386   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     387   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     388   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub. 3                                                                         CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     389   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              390   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              391   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     392   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              393   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              394   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              395   CH.sub.3                                                                            C(O)H                                                                               OH   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              396   CH.sub.3                                                                            C(O)H                                                                               OH   H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              397   CH.sub.3                                                                            C(O)H                                                                               OH   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              398   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              399   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              400   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     401   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     402   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     403   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              404   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              405   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     406   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              407   CH.sub.3                                                                            C(O)H                                                                               OH   CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              408   CH.sub.3                                                                            C(O)H                                                                               OH   CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              409   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              410   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              411   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              412   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              413   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              414   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     415   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     416   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     417   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              418   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              419   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     420   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              421   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              422   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              423   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               H     CH.sub. 3                                                                         CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              424   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              425   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              426   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              427   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              428   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     429   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   H                                           430   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     431   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              432   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              433   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     434   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              435   CH.sub. 2 CH.sub.3                                                                  OH   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              436   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              437   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              438   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              439   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              440   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              441   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              442   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     443   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     444   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     445   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              446   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              447   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     448   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              449   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              450   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              451   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              452   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              453   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              454   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              455   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              456   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     457   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     458   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     459   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              460   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              461   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     462   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              463   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              464   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              465   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              466   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              467   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              468   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub. 3                                                                         H    CH.sub.3                                                                             CH.sub.3                              469   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              470   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     471   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     472   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     473   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              474   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              475   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     476   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              477   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              478   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              479   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              480   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub. 2 CH.sub.3                                                                  CH.sub.3                                                                             CH.sub.3                              481   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           H     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              482   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              483   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                              484   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     485   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    H                                     486   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             H                                     487   OCH.sub.3                                                                           OC(O)H                                                                              OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              488   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              489   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             H                                     490   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              491   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                   H  CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              492   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH(CH.sub.3).sub. 2                                                                  CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                              493   H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              494   H    H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              495   H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              496   H    H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              497   H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              498   H    CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              499   H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              500   H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              501   H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              502   H    CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              503   CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              504   CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              505   CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              506   CH.sub.3                                                                            H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              507   CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              508   CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              509   CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              510   CH.sub.3                                                                            CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              511   CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              512   CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              513   CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              514   CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              515   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              516   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              517   CH.sub.3                                                                            OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              518   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              519   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              520   CH.sub.3                                                                            OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              521   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              522   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              523   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              524   CH.sub.2 CH.sub.3                                                                   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              525   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              526   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub. 3                                                                           CH.sub.3                                                                             CH.sub.3                              527   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              528   CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              529   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              530   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              531   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              532   CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              533   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              534   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              535   CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              536   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              537   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              538   CH.sub.2 CH.sub.3                                                                   OH   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              539   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              540   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              541   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              542   OCH.sub.3                                                                           H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              543   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              544   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              545   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              546   OCH.sub.3                                                                           CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              547   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              548   OCH.sub. 3                                                                          CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              549   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              550   OCH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              551   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              552   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              553   OCH.sub.3                                                                           OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              554   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              555   OH   H    C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              556   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              557   OH   H    C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              558   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              559   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              560   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              561   OH   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              562   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              563   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              564   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              565   OH   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              566   CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              567   CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              568   CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              569   CH.sub.3                                                                            C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              570   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              571   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              572   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              573   CH.sub.3                                                                            C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              574   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              575   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              576   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              577   CH.sub.3                                                                            C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              578   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              579   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              580   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              581   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              582   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              583   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              584   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              585   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              586   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              587   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              588   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              589   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              590   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              591   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              592   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              593   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              594   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              595   CH.sub.2 CH.sub.3                                                                   C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              596   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              597   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              598   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              599   OCH.sub.3                                                                           C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              600   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              601   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              602   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              603   OCH.sub.3                                                                           C(O)H                                                                               CH.sub. 3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              604   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              605   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              606   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              607   OCH.sub.3                                                                           C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              608   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              609   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              610   OCH.sub.3                                                                           C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              611   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              612   OH   C(O)H                                                                               H    CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              613   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              614   OH   C(O)H                                                                               H    CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub. 2 CH.sub.3                                                                   CH.sub.3                              615   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              616   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              617   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              618   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              619   OH   C(O)H                                                                               CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                   CH.sub.3                              620   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              621   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              622   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              623   OH   C(O)H                                                                               CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              624   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              625   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              626   CH.sub.3                                                                            C(O)H                                                                               OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              627   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                              628   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                              629   CH.sub.3                                                                            C(O)H                                                                               OH   CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH.sub.3                              __________________________________________________________________________

The novel alkyl indane aldehyde compounds of the present invention, with their musk aroma properties, have high utility in the fragrance industry. These compounds can be employed alone, in combination with one another, and/or in combination with one or more ingredients to provide excellent musk fragrance compositions. The compounds of the invention are particularly useful in rounding off compositions, and blend particularly well with aldehydes of various fragrance types.

For example, the compounds of Formula [I] may be used as olfactory components in anionic, cationic, nonionic and zwitterionic detergents, soaps, fabric softener compositions, fabric softener articles for use in clothes dryers, space odorants and deodorants, perfumes, colognes, toilet water, toiletries, bath preparations, deodorants, cosmetics, hand lotions, sunscreens, powders, as well as in other ways. The amount of the subject compounds to be used in modifying the olfactory or fragrance properties of a composition (that is, modifying, augmenting, enhancing, or improving the aroma of such compositions), will vary depending upon the particular use intended, as will be readily apparent to those skilled in the art. Although they may be present in major or minor amounts, preferably, because of the strength of their odor, the compounds of the invention are generally employed as a minor ingredient, that is, in an amount of about 0.1 percent by weight of the fragrance composition up to about 50 percent by weight of the fragrance composition, preferably about 0.1 percent by weight up to about 30 percent by weight of the fragrance composition, and most preferably about 0.1 percent by weight up to about 5.0 percent by weight of the fragrance composition. Within these basic parameters, the olfactorily effective amount (that is, the amount of the compounds of Formula [I] effective to modify, augment, enhance or improve the aroma properties of a composition) will be well within the ambit of one skilled in the art, once armed with the present disclosures.

The fragrance compositions of the invention may, if desired, contain a carrier or vehicle (as used herein, the term "carrier" shall be considered synonymous with the term "vehicle"). Such carriers include liquids such as a non-toxic alcohol, a non-toxic glycol, or the like. An example of a non-toxic alcohol is ethyl alcohol. An example of a non-toxic glycol is 1,2-propylene glycol. Alternatively, the carrier can be an absorbent solid such as a gum, e.g., gum arabic, xantham gum or guar gum, or components for encapsulating a composition such as gelatin, by means of coacervation or such as a urea formaldehyde polymer whereby a polymeric shell is formed around a liquid perfume oil center. The amount of the vehicle or carrier will vary depending upon the particular vehicle or carrier employed and use intended, as will be readily apparent to those skilled in the art. However, the vehicle or carrier can generally be employed in an amount of about 5 percent by weight up to about 95 percent by weight of the fragrance composition.

The fragrance composition may alternatively or additionally contain other perfumery materials. Typical additional perfumery materials which may form part of compositions of the invention include: natural essential oils such as lemon oil, mandarin oil, clove leaf oil, petitgrain oil, cedar wood oil, patchouli oil, lavandin oil, neroli oil, ylang oil, rose absolute or jasmine absolute; natural resins such as labdanum resin or olibanum resin; single perfumery chemicals which may be isolated from natural sources or manufactures synthetically, as for example, alcohols such as geraniol, nerol, citronellol, linalol, tetrahydrogeraniol, β-phenylethyl alcohol, methyl phenyl carbinol, dimethyl benzyl carbinol, menthol or cedrol; acetates and other esters derived from such alcohols; aldehydes such as citral, citronellal, hydroxycitronellal, lauric aldehyde, undecylenic aldehyde, cinnamaldehyde, amyl cinnamic aldehyde, vanillin or heliotropin; acetals derived from such aldehydes; ketones such as methyl hexyl ketone, the ionones and the methylionones; phenolic compounds such as eugenol and isoeugenol; other synthetic musks such as musk xylene, musk ketone, hexamethylisochroman, 5-acetyl-isopropyltetramethylindane, 6-acetyl-hexamethyltetralin (TETRALIDE®, a registered trademark of Bush Boake Allen Limited), 5-acetyl-hexamethylindane and ethylene brassylate; and other materials commonly employed in the art of perfumery. Typically at least five, and usually at least ten, of such materials will be present as components of the active ingredient. The amount of the additional perfumery material will vary depending upon the particular perfumery material employed and use intended, as will be apparent to those skilled in the art.

Fragrance compositions and preparatory techniques are well known in the art, and are disclosed, for example, in "Soap, Perfumery and Cosmetics", by W. A. Poucher, 7th edition, published by Chapman & Hall (London) (1959); "Perfume and Flavour Chemicals", by S. Arctander, published by the author (Montclair) (1959); and "Perfume and Flavour Materials of Natural Origin", also by S. Arctander, self-published (Elizabeth, N.J.) (1960), the disclosures of each of which are incorporated herein by reference, in their entirety.

The invention is further described in the following Examples 1-6, which are prophetic examples illustrating methods of preparation for compounds of the present invention.

Example 1 describes the preparation of 5-formyl-1-isopropyl-2,3,3,4,6-pentamethylindane, a compound of Formula [I] wherein R₁ is CH₃, R₂ is C(O)H, R₃ is CH₃, R₄ is CH(CH₃)₂, R₅ is H, R₆ is CH₃, R₇ is CH₃, and R₈ is CH₃.

Example 2 describes the preparation of 5-formyl-1-isopropyl-2,3,3,6-tetramethylindane, a compound of Formula [I] wherein R₁ is H, R₂ is C(O)H, R₃ is CH₃, R₄ is CH(CH₃)₂, R₅ is H, R₆ is CH₃, R₇ is CH₃, and R₈ is CH₃.

Example 3 describes the preparation of 5-formyl-1-isopropyl-2,3,3,6-tetramethyl-4-methoxyindane, a compound of Formula [I] wherein R₁ is OCH₃, R₂ is C(O)H, R₃ is CH₃, R₄ is CH(CH₃)₂, R₅ is H, R₆ is CH₃, R₇ is CH₃, and R₈ is CH₃.

Example 4 describes the preparation of 5-formyl-1-isopropyl-2,3,3,4-tetramethyl-6-methoxyindane, a compound of Formula [I] wherein R₁ is CH₃, R₂ is C(O)H, R₃ is OCH₃, R₄ is CH(CH₃)₂, R₅ is H, R₆ is CH₃, R₇ is CH₃, and R₈ is CH₃.

Example 5 describes the preparation of 5-formyl-1,1,2,3,3,4-hexamethyl-6-methoxyindane, a compound of Formula [I] wherein R₁ is CH₃, R₂ is C(O)H, R₃ is OCH₃, R₄ is CH₃, R₅ is CH₃, R₆ is CH₃, R₇ is CH₃, and R₈ is CH₃.

Example 6 describes the preparation of 5-formyl-1,1,2,3,3,6-hexamethyl-4-methoxyindane, a compound of Formula [I] wherein R₁ is OCH₃, R₂ is C(O)H, R₃ is CH₃, R₄ is CH₃, R₅ is CH₃, R₆ is CH₃, R₇ is CH₃, and R₈ is CH₃.

These examples are intended to be illustrative only, and are not to be construed as limiting the scope of the appended claims.

EXAMPLE 1

Preparation of 5-Formyl-1-Isopropyl-2,3,3,4,6-Pentamethylindane

Isopropylmagnesium chloride (2.0M, 100 ml, 0.2 moles) (which may be obtained from Aldrich Chemical Company, Inc., Milwaukee, Wis.) in ether is added at room temperature to a 250 ml four-necked round bottom flask equipped with an air stirrer, septum, Claisen adapter (thermocouple and dry ice condenser attached) and nitrogen inlet tube. To this is then slowly added 3,5-dimethylbenzaldehyde (24.46 g) (which may be obtained from Lancaster Synthesis, Inc., Windham, N.H.). After about 2 hours, an aliquot of additional Grignard (20 ml) is added. The solution is then heated at 60° C. for about one hour, and quenched with aqueous NH₄ Cl. The aqueous layer is then washed several times with methyl tert-butyl ether and rotoevaporated to yield a crude product mixture containing 2-methyl-1-[3',5'-dimethylphenyl]-1-propanol. The product mixture is then fractionated under reduced pressure to further purify the 2-methyl-1-[3',5'-dimethylphenyl-1-propanol compound.

Next, 2-methyl-1-[3',5'-dimethylphenyl-1-propanol is converted to 1-isopropyl-2,3,3,4,6-pentamethylindane by following procedures similar to those described in European Patent Application Publication No. 0 393 742. Specifically, to a stirred solution of 10 ml TiCl₄, in 120 ml dichloromethane which has been cooled to -5° C. under nitrogen, is added a mixture of 17.8 g 2-methyl-1-[3',5'-dimethylphenyl-1-propanol, and 14.0 g 2-methyl-2-butene over a two hour period. The reaction mixture is stirred for a further 30 min at -5° C. Thereafter, it is poured into a mixture of 200 ml water and 100 ml concentrated hydrochloric acid and stirred for 15 min. The organic phase is separated and the aqueous phase washed with brine with 50 ml dichloromethane. The combined organic phase is washed twice with 100 ml 10% hydrochloric acid solution, once with 100 ml water, twice with 100 ml 5% sodium carbonate solution, and finally, once again, with water. Solvent is then removed, yielding 1-isopropyl-2,3,3,4,6-pentamethylindane, which is further purified using reduced pressure fractional distillation techniques.

The compound 1-isopropyl-2,3,3,4,6-pentamethylindane is then treated as follows to yield 5-formyl-1-isopropyl-2,3,3,4,6-pentamethylindane. Specifically, 1-isopropyl-2,3,3,5,6-pentamethylindane (12.96 g) is placed in a 1 liter three-necked round bottom flask equipped with a reflux condenser, a stirrer and a dropping funnel. In accordance with the general procedures described in Organic Syntheses, Collective Vol. 5, pp. 49-50, by A. Rieche, H. Gross, and E. Hoft, edited by H. E. Baumgarten, John Wiley and Sons (New York, N.Y. 1973), methylene chloride (37.5 ml) is added to the flask. The solution is then cooled in an ice bath, and titanium tetrachloride (19.0 g) is added over a period of about 3 minutes. While the solution is stirred and cooled, α,α-dichloromethyl methyl ether (5.75 g) is added dropwise over a 25 minute period. After the addition is complete, the mixture is stirred for about 5 minutes in the ice bath, for about 30 minutes without cooling, and for about 15 minutes at about 35° C. The reaction mixture is then poured into a separatory funnel containing about 50 g of crushed ice and is shaken thoroughly. The organic layer is separated, and the aqueous solution is extracted with two 10 ml portions of methylene chloride. The combined organic solution is washed three times with 10 ml portions of water. A crystal of hydroquinone is added to the methylene chloride solution, which is then dried over anhydrous sodium sulfate. After evaporation of the solvent, the residue is distilled to yield, as a crude product, 5-formyl-1-isopropyl-2,3,3,4,6-pentamethylindane. The 5-formyl-1-isopropyl-2,3,3,4,6-pentamethylindane is then further purified using standard fractional distillation techniques.

EXAMPLE 2

Preparation of 5-Formyl-1-Isopropyl-2,3,3,6-Tetramethylindane

Isopropylmagnesium chloride (2.0M, 100 ml, 0.2 moles) (which may be obtained from Aldrich Chemical Company, Inc., Milwaukee, Wis.) in ether is added at room temperature to a 250 ml four-necked round bottom flask equipped with an air stirrer, septum, Claisen adapter (thermocouple and dry ice condenser attached) and nitrogen inlet tube. To this is then slowly added meta-tolualdehyde (24.46 g). After about 2 hours, an aliquot of Grignard (20 ml) is added. The reaction is then heated at 60° C. for about one hour, and quenched with aqueous NH₄ Cl. The aqueous layer is then washed several times with methyl tert-butyl ether and rotoevaporated to yield a crude product mixture containing 2-methyl-1-[3'-methylphenyl]-1-propanol. The product mixture is then fractionated under reduced pressure further purify 2-methyl-1-[3'-methylphenyl]-1-propanol. The compound 2-methyl-1-[3'-methylphenyl]-1-propanol is then converted to 1-isopropyl-2,3,3,6-tetramethylindane by following the procedures of Example 1.

The compound 1-isopropyl-2,3,3,6-tetramethylindane is then treated as described in Example 1 to yield 5-formyl-1-isopropyl-2,3,3,6-tetramethylindane.

EXAMPLE 3

Preparation of 5-Formyl-1-Isopropyl-2,3,3,6-Tetramethyl-4-Methoxyindane

Isopropylmagnesium chloride (2.0M, 100 ml, 0.2 moles) (which may be obtained from Aldrich Chemical Company, Inc., Milwaukee, Wis.) in ether is added at room temperature to a 250 ml four-necked round bottom flask equipped with an air stirrer, septum, Claisen adapter (thermocouple and dry ice condenser attached) and nitrogen inlet tube. To this is then slowly added 3-methoxy-5-methyl benzaldehyde (24.46 g), which may be prepared in accordance with the procedures of Syper, Tetrahedron Letters, No. 37, pp. 4493-4498 (1966). After about 2 hours, an aliquot of Grignard (20 ml) is added. The solution is then heated at 60° C. for about one hour, and quenched with aqueous NH₄ Cl. The aqueous layer is then washed several times with methyl tert-butyl ether and rotoevaporated to yield a crude product mixture containing 2-methyl-1-[3'-methoxy-5'-methylphenyl]-1-propanol. The product mixture is then fractionated under reduced pressure to further purify 2-methyl-1-[3'-methoxy-5'-methylphenyl]-1-propanol.

The compound 2-methyl-1-[3'-methoxy-5'-methylphenyl]-1-propanol is then converted to a mixture of 1-isopropyl-2,3,3,6-tetramethyl-4-methoxyindane and 1-isopropyl-2,3,3,4-tetramethyl-6-methoxyindane by following the procedures of Example 1. The mixture of indanes is then subjected to vacuum spinning band distillation techniques to separate out the 1-isopropyl-2,3,3,6-tetramethyl-4-methoxyindane compound.

The 1-isopropyl-2,3,3,6-tetramethyl-4-methoxyindane compound is then treated as described in Example 1 to yield 5-formyl-1-isopropyl-2,3,3,6-tetramethyl-4-methoxyindane.

EXAMPLE 4

Preparation of 6-Formyl-1-Isopropyl-2,3,3,4-Tetramethyl-5-Methoxyindane

The procedures of Example 3 are substantially carried out, except that the compound 1-isopropyl-2,3,3,4-tetramethyl-6-methoxyindane is isolated from the indane mixture using vacuum spinning band distillation techniques for further use.

The compound 1-isopropyl-2,3,3,4-tetramethyl-6-methoxyindane is then treated as described in Example 1 to yield 6-formyl-1-isopropyl-2,3,3,4-tetramethyl-5-methoxyindane.

EXAMPLE 5

Preparation of 5-Formyl-1,1,2,3,3,4-Hexamethyl-6-Methoxyindane

Methylmagnesium bromide (3.0M, 100 ml) (which may be obtained from Aldrich Chemical Company, Inc., Milwaukee, Wis.) in ether is added at room temperature to a 250 ml four-necked round bottom flask equipped with an air stirrer, septum, Claisen adapter (thermocouple and dry ice condenser attached) and nitrogen inlet tube. To this is then slowly added a mixture of 2,3-dimethyl-4-methoxyacetophenone and 3,4-dimethyl-2-methoxyacetophenone (24.46 g). The mixture of acetophenones may be prepared using the Perrier modification (CH₃ C(O)Cl, aluminum chloride and methylene chloride) in accordance with the procedures of Perrier, Chem. Ber., Vol. 33, pp. 819 et seq. (1900), and Perrier, Bull. Soc. Chim. France, pp. 859 et seq. (1904). After about 2 hours, an aliquot of additional Grignard (20 ml) is added. The solution is then heated at 60° C. for about one hour, and quenched with aqueous NH₄ Cl. The aqueous layer is then washed several times with methyl tert-butyl ether and rotoevaporated to yield a crude product mixture containing 1-methyl-1-[2'-methoxy-3',4'-dimethylphenyl]-ethanol or 1-methyl-1-[4'-methoxy-2',3'-dimethylphenyl]-ethanol. The product mixture is then subjected to spinning band distillation procedures to separate out the 1-methyl-1-[4'-methoxy-2',3'-dimethylphenyl]-ethanol compound. The compound 1-methyl-1-[4'-methoxy-2',3'-dimethylphenyl]-ethanol is then converted to 1,1,2,3,3,4-hexamethyl-6-methoxyindane by following the procedures of Example 1.

The 1,1,2,3,3,4-hexamethyl-6-methoxyindane (10.8 g) is then heated with copper(II) sulfate pentahydrate (18.04 g) and potassium peroxydisulfate (60.55 g) in acetonitrile and water (1:1, 500 ml) at reflux for about 15 to 20 minutes, following procedures similar to those described in Hauser et al., Synthesis, pp. 723-724 (1987). The mixture is then cooled to room temperature and methylene chloride (150 ml) is added. The layers are separated and the aqueous phase is further extracted with additional methylene chloride (2×70 ml). The combined organic solutions are dried with anhydrous sodium sulfate, filtered, and evaporated at reduced pressure to yield 5-formyl-1,1,2,3,3,4-hexamethyl-6-methoxyindane.

EXAMPLE 6

Preparation of 5-Formyl-1,1,2,3,3,6-Hexamethyl-4-Methoxyindane

The procedures of Example 5 are substantially carried out, except that the compound 1-methyl-1-[2'-methoxy-3',4'-dimethylphenyl]-ethanol is isolated from the indane mixture using standard fractional distillation techniques, and used to prepare 1,1,2,3,3,6-hexamethyl-4-methoxyindane.

The compound 1,1,2,3,3,6-hexamethyl-4-methoxyindane is then treated as described in Example 5 to yield 5-formyl-1,1,2,3,3,6-hexamethyl-4-methoxyindane.

The disclosures of each patent and publication cited or described herein are hereby incorporated herein by reference, in their entirety.

Various modifications of the invention, in addition to those shown and described herein, will be readily apparent to those skilled in the art from the foregoing description. Such modifications are also intended to fall within the scope of the appended claims. 

What is claimed is:
 1. A compound of the formula: ##STR6## wherein R¹ is H, CH₃, CH₂ CH₃, OCH₃ or OH,R² and R³ are, independently, H, CH₃, CH₂ CH₃, OCH₃, OH or C(O)H, R⁴ and R⁷ are, independently, H, CH₃, CH₂ CH₃ or CH(CH₃)₂, R⁵ and R⁸ are, independently H or CH₃, and R⁶ is H, CH₃ or CH₂ CH₃, provided that(i) one of R² and R³ is C(O)H, and one of R² and R³ is other than C(O)H, (ii) when R¹ is H, then R² and R³ are other than OCH₃ or OH, (iii) when R¹ is other than H, then R⁷ is CH₃ or CH₂ CH₃, (iv) no more than one of R⁴, R⁶ and R⁷ is CH₂ CH₃ or CH(CH₃)₂, (v) no more than one of R⁴, R⁵, R⁶, R⁷ and R⁸ is H, (vi) when each of R¹, R³, R⁴ and R⁵ are CH₃, then R⁸ is H, (vii) when R⁴ is CH(CH₃)₂, then at least one of R⁵ or R⁶ is H, (viii) when R⁷ is CH(CH₃)₂, then at least one of R⁶ or R⁸ is H, (ix) when R¹ is OCH₃, then R² and R³ are other than OH, (x) when R¹ is OH, then R² and R³ are other than OH or OCH₃, (xi) when R¹ is H, R⁴ is CH(CH₃)₂ and R⁵ is CH₃, then one of R² and R³ is CH₂ CH₃, (xii) when R¹ is H, R⁷ is CH(CH₃)₂ and R⁸ is CH₃, then one of R² and R³ is CH₂ CH₃, (xiii) when R¹ is H, R⁷ is CH(CH₃)₂ and R⁸ is H, then R³ is C(O)H, (xiv) when R¹ is H, R⁴ is CH(CH₃)₂ and R⁵ is H, then R² is C(O)H, (xv) when R¹ is H, R⁷ is CH₂ CH₃ and R⁴, R⁵ and R⁸ is CH₃, then both of R² and R³ are other than CH₃, (xvi) when R¹ is H, R⁴ is CH₂ CH₃ and R⁵, R⁷ and R⁸ is CH₃, then both of R² and R³ are other than CH₃, and (xvii) when one of R² and R³ is CH₃, and each of R⁴, R⁵, R⁶, R⁷ and R⁸ are CH₃, then R¹ is other than H.
 2. A compound of claim 1 wherein R² is C(O)H.
 3. A compound of claim 1 wherein at least one of R¹, R² and R³ are independently OCH₃ or OH.
 4. A compound of claim 3 wherein at least one of R¹, R² and R³ are OCH₃.
 5. A compound of claim 1 wherein R¹ is H, CH₃, CH₂ CH₃ or OCH₃, and R² and R³ are, independently, H, CH₃, CH₂ CH₃, OCH₃ or C(O)H.
 6. A compound of claim 5 wherein R¹ is H, CH₃ or OCH₃, and R² and R³ independently are H, CH₃, OCH₃ or OC(O)H.
 7. A compound of claim 1 wherein at least one of R⁴ or R⁷ are H, CH₃ or CH₂ CH₃.
 8. A compound of claim 1 wherein R⁴ and R⁷ are, independently, CH₃, CH₂ CH₃ or CH(CH₃)₂, and R⁵ and R⁸ are CH₃.
 9. A compound of claim 8 wherein R⁶ is CH₃ or CH₂ CH₃.
 10. A compound of claim 1 wherein R⁴ is CH(CH₃)₂.
 11. A compound of claim 1 wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.
 12. A compound of claim 1 wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.
 13. A compound of claim 1 wherein R¹ is CH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₂ CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₃ and R⁸ is CH₃.
 14. A compound of claim 1 wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH₂ CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₃ and R⁸ is CH₃.
 15. A compound of claim 1 wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₂ CH₃ and R⁸ is CH₃.
 16. A compound of claim 1 wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₂ CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₃ and R⁸ is CH₃.
 17. A compound of claim 1 wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH₃, R⁵ is CH₃, R⁶ is H, R⁷ is CH₂ CH₃ and R⁸ is CH₃.
 18. A compound of claim 1 wherein R¹ is CH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.
 19. A compound of claim 1 wherein R¹ is CH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.
 20. A compound of claim 1 wherein R¹ is OCH₃, R² is C(O)H, R³ is CH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.
 21. A compound of claim 1 wherein R¹ is OCH₃, R² is C(O)H, R³ is OCH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.
 22. A compound of claim 1 wherein R¹ is H, R² is C(O)H, R³ is CH₃, R⁴ is CH(CH₃)₂, R⁵ is H, R⁶ is CH₃, R⁷ is CH₃ and R⁸ is CH₃.
 23. A fragrance composition comprising a compound of claim 1 in combination with at least one of a carrier and additional perfumery material.
 24. A fragrance composition comprising a compound of claim 21 in combination with at least one of a carrier and additional perfumery material.
 25. A method of modifying the olfactory properties of a composition comprising adding thereto an olfactorily effective amount of a compound of claim
 1. 26. A method of modifying the olfactory properties of a composition comprising adding thereto an olfactorily effective amount of a compound of claim
 21. 27. A product produced by the method of claim
 25. 28. A product produced by the method of claim
 26. 